Figure 9
The inhibitory effect of bilirubin on nAChR currents persisted in the presence of 1 μM H-89.
(A) Representative traces of nAChR currents inhibited by 4 μM bilirubin persisted in the presence of 1 μM H-89. (B) The dose-response relationship for bilirubin on ACh-induced peak currents persisted in the presence of 1 μM H-89. The response rates of ACh-induced currents by bilirubin were normalized to the control response induced by 100 μM ACh. (C) The dose-response relationship for bilirubin on desensitization of nAChR persisted in the presence of 1 μM H-89. Desensitization of nAChRs by bilirubin was normalized to the control response induced by 100 μM ACh. Each data point is expressed as means ± SEMs (n = 5).
