Figure 7
From: Nicotine exposure and transgenerational impact: a prospective study on small regulatory microRNAs
Nicotine exerts its transgenerational effect via five enriched gene candidates.
(a) A network showing relationships between differentially altered miRNAs with gene candidates in each generation. Triangles denote worms of the F0 generations, while squares and circles denote worms of the F1 and F2 generations, respectively. The five genes candidates are in hexagons in the middle. The low concentration treatment groups are shown on the up-right side, while the high concentration treatment groups are shown in the left bottom side. (b) A simplified network showing interactions between only commonly altered miRNAs and the candidate genes. Candidate genes are in yellow. miRNAs targeting more than one gene are in green. (c) A hypothesized model to explain the nicotine-induced miRNA expression profiles and behaviors as a function of duration of exposure or abstinence and previous parental life experiences.
