Figure 6
From: The EHEC-host interactome reveals novel targets for the translocated intimin receptor
Tir subnetworks.
(a) TIR and other effectors are highly interconnected with human proteins. Detected, published and detected/published interactions are depicted in black, blue and red, respectively. BAIAP2L1 (not depicted) also interacts with EspFu and TIR and thus plays a homologous role as BAIAP2. (b) EHEC TIR directly targets three calcium binding proteins of the VILIP family. Possible targeted pathways are indicated. (c) IKBKG ( = NEMO) is indirectly targeted by three effector proteins, TIR, EspB and NleB1. In addition, the NF-kB pathway is targeted by several effector proteins such as the metalloprotease NleC. Furthermore, NleH inhibits NF-kB signaling and NleB1 targets glyceraldehyde 3-phosphate dehydrogenase (GAPDH) while interfering with the signaling cascade through TRAF2. For previously published interactions see Suppl. Table S3.
