Figure 4

Deficiency of IL-17 facilitates basal synaptic transmission in DG of hippocampal slices.

(A). For field potential recordings from slices of hippocampal DG, the stimulating electrode was placed in the angular bundle of the perforant path and a recording electrode in the hilus of the DG. (B). LTP recordings from the adult hippocampus DG shows no difference between WT and IL-17KO mice. (C). Input/output (I/O) curves relating the various input intensity (mV) to the slope of fEPSP in the DG region of adult IL-17 KO and WT mice. (D). Enhanced paired-pulse facilitation in the DG of hippocampal slices from IL-17 KO mice. Paired-pulse facilitation across different inter-stimulus intervals (50–500 ms) is increased in the DG of hippocampal slices from IL-17 KO mice. (n = 6 mice per group). Means ± SEM; **p < 0.01.