Figure 6
From: Interleukin-17 inhibits Adult Hippocampal Neurogenesis
Endogenous IL-17 regulates the expression of proneuronal and progial genes.
Real-time RT-PCR analysis of the messenger expression levels of promeuronal genes (NGN2, MASH1 and NeuroD1) and proglia genes (HES1 and ld2) in cultured NPCs from IL-17 KO and WT mice. The mRNA expression of NGN2, Mash1 and NeuroD1 were increased in IL-17 KO progenitor cells compared with WT controls. Proglial gene expressions of HES1 and ld2 were decreased in IL-17 KO progenitors as compared to WT controls. Data were obtained from four individual experiments performed in triplicate. Means ± SEM; *p < 0.05; **p < 0.01.
