Figure 1 | Scientific Reports

Figure 1

From: Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate

Figure 1

Bone substrate regulates gene expression in differentiating murine osteoclasts.

(a) Phalloidin stain showing distinctive actin morphology of wild type BMM-derived osteoclasts differentiated on bone. (b) Phalloidin stain showing distinctive actin morphology of wild type BMM-derived osteoclasts differentiated on plastic. (c) Hierarchical clustering heat map of mouse BMM-derived osteoclast expression profiles regulated by RANKL, stage of differentiation and culture substrate. (d) Total numbers of RANKL-induced genes that are further regulated, or unaffected, by bone substrate. (e) Venn diagram of the overlap between genes regulated >2× by bone on days 1, 3 and 5.

Back to article page