Figure 1
From: Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy
Combination of ACP and BCL acts synergistically to protect neurons and microvascular HBMEC tubules from the toxicity of Aβ1–42 oligomers.
Normalised data for the difference between Aβ1–42 oligomer-treated and untreated cultures are presented. The dose-response curve of ACP in primary neurons and HBMEC (a,d) showed a bell-shaped protective aspect in both assays, while that of BCL was sigmoid (b,e). At sub-active concentrations of individual drugs, ABC was active with a synergistic effect on neuronal (c) (n = 7) and HBMEC tubular (f) (n = 3) protection. BDNF (c) and VEGF (f) were used as controls. All values are mean ± s.e.m. **P < 0.01, ***P < 0.001 versus Aβ; ANOVA with Dunnett's test. S: Synergy.
