Figure 6
From: Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy
ABC preserves phenotypic alterations occurring in vivo in Aβ25–35-injected animals.
ABC protected the BBB from leakage as assessed by Evans Blue dye in brain after systemic injection (a) (n = 12) and preserved hippocampal CA1 pyramidal cells (b) (n = 12). (b) Representative images of Cresyl violet-stained hippocampal CA1 neurons before and after ABC treatment. Hippocampal CA1 pyramidal cells were counted from 8 slices per animal and 6 mice per group and results were expressed as number of neurons per mm. ABC was composed of ACP 0.2 mg Kg−1 and BCL 3 mg Kg−1. Values are mean ± s.e.m. ***P < 0.001 versus Aβ; ANOVA with Dunnett's test. Sc.: scrambled.
