Figure 4
From: Distinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ production
p21 overexpression reduces in vivo T cell hyperproliferation.
(a) Transgenic p21 expression reduced in vivo BrdU incorporation by B6/lpr CD4+, CD8+ and DN T cells. Data show mean ± SD (n = 4 mice; p < 10−5 for the three T cell types). (b) Similar BrdU incorporation for control B6 and B6-p21tg CD4+, CD8+ and DN T cells. (c) p21 transgenic expression reduced in vivo BrdU incorporation by effector (CD44hiCD62Lhi) and memory (CD44hiCD62Llo) B6/lpr T cells. (d) B6 and B6-p21tg effector and memory T cells showed similar in vivo BrdU incorporation. T cells were obtained from 2-month-old mice given BrdU in drinking water for 9 days. For (c) and (d) representative histograms are shown; mean ± SD (n = 4 mice).
