Figure 5
From: A glucose carbonate apatite complex exhibits in vitro and in vivo anti-tumour effects
CA-[Glc] toxicity.
Mice were treated with intravenous injections of a CA-[Glc] complex containing 100 mg glucose for 7 consecutive injections. (a) Body weight curves of mice and (b) blood chemistry data for no treatment and CA-[Glc] treated mice (n = 3 ~ 4, Wilcoxon rank test). (c) Blood chemistry data (days −1 ~ 4 and day 10) of Cynomolgus monkeys (n = 3). Monkeys received a 30 min CA-[Glc] i.v. infusion on days 0, 1, 2 and 3. The amount of CA for per injection corresponds to a dose of 2.5 g/kg glucose. The grey rectangle area indicates normal ranges (mean ± 2 SD). Isoenzyme analysis of CPK and LDH from blood samples on day 5 are presented together. Each isoenzyme is derived from specific organs as follows: CPK-BB, brain; CPK-MB, cardiac muscle; CPK-MM, skeletal muscle; LDH1-2, cardiac muscle, skeletal muscle, red blood cell and kidney; LDH5, liver, skin and muscle.
