Table 1 Characteristics of included studies
From: The prognostic value of phosphorylated Akt in breast cancer: a systematic review
Study | Country | Period | N | Stage | ER + (%) | PR + (%) | HER2 + (%) | pAkt + (%) | pAkt detection method | Treatment | Mean FU (year) | Outcome | HR | NOS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Al-Bazz 2009 | UK | 1994~1997 | 106 | -- | 59 | 40 | -- | 21.7 | IHC, Ser473 | S | 5.0 | OS, DFS | Uni | 5 |
Aleskandarany 2011 | UK | 1990~1998 | 1202 | 1~3 | 69 | 56 | 13 | 76.0 | IHC, Ser473 | S | 20.0 | DFS | Uni | 7 |
An 2010 | Korea | 1992~2006 | 560 | 1~3 | 57 | 49 | 24 | 55.2 | IHC, Ser473 | S | 4.9 | DFS | Multi | 7 |
Andre 2008 | France | 1989~1995 | 752 | 1~3 | 86 | 76 | 13 | 15.2 | IHC | S | 10.0 | OS, DFS | Multi | 8 |
Benesch 2010 | Germany | 1985~1995 | 160 | -- | 38 | 52 | -- | 58.1 | IHC | S | ≥13.0 | OS | Uni | 6 |
Capodanno 2009 | Italy | 1988~1998 | 72 | -- | 63 | -- | -- | 87.5 | IHC, Ser473 | S/C/R/H | 10.0 | DFS | Uni | 8 |
Cicenas 2005 | Switzerland | -- ~1996 | 156 | -- | 74 | 55 | 39 | 13.5 | IHC, Ser473 | -- | 4.8 | DFS | Multi | 8 |
Fabi 2010 | Italy | 2004~2007 | 73 | 4 | 39 | 36 | 100 | 71.2 | IHC, Ser473 | C/T | 2.0 | OS | Uni | 5 |
Gallardo 2012 | Spain | -- | 143 | 1~4 | -- | -- | 100 | 28.0 | IHC | C/T | 5.3 | OS | Uni | 5 |
Gori 2009 | Italy | 1999~2006 | 45 | 4 | 49 | 42 | 100 | 51.1 | IHC | S/T | 1.9 | OS | Uni | 5 |
Hartog 2011 | Netherland | 1996~2005 | 429 | 1~3 | 76 | 63 | 7 | 12.7 | IHC, Ser473 | C | 4.6 | DFS | Uni | 5 |
Janssen 2007 | Norwegian | 1978~1994 | 125 | 1~3 | 53 | 62 | 52 | 43.9 | IHC, Ser473 | S | 11.0 | DFS | Uni | 7 |
Kirkegaard 2005 | UK | 1983~1999 | 392 | -- | 100 | -- | 45 | 50.5 | IHC, Ser473 | C | 6.5 | OS | Uni | 6 |
Liu 2007 | China | 1996~2000 | 130 | 1~3 | 100 | -- | 31 | 46.9 | IHC, Ser473 | H | 5.1 | OS, DFS | Multi | 8 |
Nagai 2010 | Brazil | -- | 1026 | 1~4 | 67 | 45 | 14 | 48.1 | IHC, Ser473 | S | 10.0 | OS, DFS | Uni | 6 |
Perez-Tenorio 2002 | Sweden | 1984~1996 | 93 | -- | 76 | 93 | 7 | 53.8 | IHC, Ser473 | S/H | 5.3 | DFS | Multi | 8 |
Schmitz 2006 | Germany | 1989~1996 | 113 | 1~3 | 62 | 39 | 26 | 64.6 | IHC, Ser473 | S | 7.0 | OS | Multi | 8 |
Spears 2012 | UK | 1981~1998 | 1355 | 1~3 | 80 | 83 | 13 | 50.5 | IHC, Thr308 | S/R | 5.0 | OS, DFS | Multi | 8 |
Sun 2006 | China | 1994~1998 | 260 | 1~3 | -- | -- | -- | 50.0 | IHC | S | 5.0 | DFS | Uni | 7 |
Tokunaga 2006 | Japan | 1991~2002 | 240 | 1~3 | 64 | 46 | 25 | 66.3 | IHC, Ser473 | S | 12.5 | DFS | Multi | 5 |
Vestey 2005 | UK | 1996~2000 | 95 | -- | 64 | -- | 84 | 81.1 | IHC, Ser473 | S | 4.3 | OS, DFS | Multi | 5 |
Wang 2009, Wang XL 2011 | China | 1997~2007 | 110 | -- | 46 | 46 | 32 | 40.9 | IHC, Ser473 | S | 10.0 | OS, DFS | Multi* | 7 |
Wang 2010 | China | 2001~2005 | 97 | 1~3 | -- | -- | -- | 77.3 | IHC, Thr308 | S | 6.5 | OS | Uni | 6 |
Wang C 2011 | Canada | -- | 944 | 1~2 | 81 | -- | 10 | 46.7 | IHC, Ser473 | S | 10.4 | OS, DFS | Multi | 8 |
Wang AY 2011 | China | 2001~2005 | 81 | 1~3 | 78 | -- | -- | 27.2 | IHC | S | >5.0 | OS, DFS | Uni | 6 |
Wu 2008 | US | 1999~2005 | 141 | 1~4 | -- | -- | 33 | 50.4 | IHC, Ser473 | S/C | 4.0 | DFS | Multi | 9 |
Xia 2004 | China | 1988~1994 | 130 | 1~3 | 43 | 50 | 68 | 26.2 | IHC, Thr308 | S | 4.0 | OS | Uni | 7 |
Yamamoto 2006 | Japan | 1987~2002 | 221 | 1~4 | -- | -- | -- | 41.2 | IHC, Ser473 | S/C | 5.7 | OS, DFS | Multi† | 7 |
Yamashita 2008 | Japan | 1982~1999 | 278 | -- | 100 | -- | 23 | -- | IHC, Ser473 | S | 8.0 | OS, DFS | Uni | 5 |
Yonemori 2009 | Japan | 1999~2006 | 44 | 2~3 | 11 | 7 | 100 | 79.5 | IHC | S/C//T | >5.0 | DFS | Uni | 5 |
Yu 2010 | China | 2003~2007 | 98 | 1~3 | 60 | 56 | 48 | 37.8 | IHC, Ser473 | S | 3.0 | OS, DFS | Uni | 5 |
Zhou 2004 | China | 1988~1991 | 165 | -- | 50 | -- | 32 | 73.9 | IHC, Ser473 | S | 6.4 | DFS | Uni | 7 |
