Figure 2
From: Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder
Dot plots of HAMD-17 total score and subscale scores in High and Low-EA patients.
We defined MDD patients with CSF EA values below the 1st quartile as ‘Low-EA’ (N = 13) and MDD patients with CSF EA values above the 3rd quartile as ‘High-EA’ (N = 13) to compare the CSF EA levels with symptoms. Horizontal bars in dot clusters represent mean values of the groups. P-values were obtained by the Mann-Whitney U test. (a) Low-EA showed a significantly higher total score for HAMD-17 than High-EA (U = 29.0, P = 0.0033; 95% CI: 3.0 to 15.0). (b) Low-EA showed a significantly higher score for the ‘Core’ subscale than High-EA (U = 43.5, P = 0.034; 95% CI: 1.0 to 7.0). There were no significant differences between the two groups for (c) ‘Sleep’ (U = 71.5, P = 0.51; 95% CI: −1.0 to 2.0), (d) ‘Activity’ (U = 48.0, P = 0.059; 95% CI: 0.0 to 3.0) and (e) ‘Psychic Anxiety’ (U = 57.5, P = 0.17; 95% CI: 0.0 to 2.0). (f) Low-EA showed a significantly higher score for ‘Somatic Anxiety’ than High-EA (U = 18.5, P = 0.00026; 95% CI: 1.0 to 4.0). Abbreviations: HAMD-17, 17-item Hamilton Depression Rating Scale; CSF, cerebrospinal fluid; EA, ethanolamine; Low-EA, patients with CSF EA values below the 1st quartile; High-EA, patients with CSF EA values above the 3rd quartile; CI, confidence interval for the difference between two medians.
