Table 1 Associations of the 15 SNPs in discovery stage

From: Systematical analyses of variants in CTCF-binding sites identified a novel lung cancer susceptibility locus among Chinese population

      

MAF

   

SNPa

Chr.

BP.

Related gene

Infob

Allele

1000 Genomec

Cases

Controls

P Nanjing d

P Beijing d

P Combined d

rs75772117

4

6744829

BLOC1S4, KIAA0232

0.81

G > A

0.07

0.08

0.10

3.37 × 10−2

1.26 × 10−5

1.09 × 10−6

rs37010

5

1349535

CLPTM1L, SLC6A3

0.98

A > G

0.17

0.13

0.16

4.16 × 10 −3

1.73 × 10 −4

2.67 × 10 −6

rs10072980

5

33181214

LOC340113, TARS

0.90

T > C

0.14

0.15

0.18

2.88 × 10−3

9.80 × 10−5

2.77 × 10−7

rs1632447

6

29688886

ZFP57, HLA-F

0.99

C > A

0.02

0.03

0.02

3.57 × 10−2

3.79 × 10−7

2.05 × 10−6

rs114731497

6

29653824

ZFP57, HLA-F

0.98

C > G

0.02

0.04

0.02

8.65 × 10−4

3.53 × 10−7

3.22 × 10−8

rs115786093

6

30451515

TRIM39-RPP21, HLA-E

0.92

G > A

0.05

0.04

0.03

1.45 × 10−5

1.57 × 10−3

1.31 × 10−6

rs115364068

6

30325531

TRIM39-RPP21, HLA-E

0.98

T > C

0.07

0.07

0.05

1.62 × 10−4

2.15 × 10−8

1.88 × 10−9

rs115299438

6

31164828

HCG27

1.00

C > A

0.09

0.10

0.13

4.88 × 10−4

8.94 × 10−5

7.32 × 10−6

rs2252937

6

31461613

HCG26, MICB

0.89

T > C

0.08

0.14

0.11

3.38 × 10−3

7.89 × 10−5

3.86 × 10−6

rs2002059

10

101130855

CNNM1

0.83

A > G

0.09

0.07

0.09

1.84 × 10 −2

1.39 × 10 −8

1.07 × 10 −8

rs3124203

10

30799716

MAP3K8, LYZL2

0.92

C > G

0.10

0.07

0.10

3.04 × 10−2

3.67 × 10−4

9.54 × 10−6

rs60507107

11

61463769

DAGLA

0.99

C > T

0.36

0.39

0.35

4.99 × 10 −3

8.48 × 10 −4

4.93 × 10 −6

rs11617518

13

24290267

TNFRSF19, MIPEP

1.00

C > T

0.32

0.32

0.28

6.97 × 10−4

9.03 × 10−4

4.07 × 10−6

rs12100587

14

106004323

TMEM121, ELK2AP

0.88

T > G

0.44

0.41

0.47

1.65 × 10−3

1.16 × 10−9

1.76 × 10−10

rs2836333

21

39724700

KCNJ15, ERG

0.80

A > G

0.24

0.24

0.27

1.63 × 10−2

2.71 × 10−4

5.42 × 10−6

  1. a: all selected SNPs were identified by Imputation;
  2. b: imputed quality info;
  3. c: minor allele frequency of ASN in 1000 Genome;
  4. d: adjusted by age, gender, pack-year of smoking and pca1.
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