Table 2 Associations of the 2 replicated SNPs in GWAS and replicated stage

From: Systematical analyses of variants in CTCF-binding sites identified a novel lung cancer susceptibility locus among Chinese population

  

GWAS

Validation

Combined

SNP (cytoband, BP)

Genotype

Cases/Controls

OR (95%CI)a

P a

Cases/Controls

OR (95%CI)b

P b

OR (95%CI)a

P a

rs2002059

AA

2020/2587

1.00

 

929/1141

1.00

 

1.00

 

10q24.2, 101130855

AG

306/469

0.73(0.63–0.85)

6.75 × 10−5

160/185

1.06(0.85–1.34)

5.90 × 10−1

0.91(0.80–1.04)

1.62 × 10−1

 

GG

5/21

0.23(0.10–0.55)

9.27 × 10−4

10/7

1.77(0.67–4.68)

2.51 × 10−1

0.73(0.38–1.39)

3.36 × 10−1

 

Additive

 

0.62(0.53–0.73)

1.07 × 10−8

 

1.11(0.90–1.37)

3.39 × 10−1

0.90(0.80–1.02)

1.01 × 10−1

rs60507107

CC

871/1300

1.00

 

428/556

1.00

 

1.00

 

11q12.2, 61463769

CT

1118/1429

1.20(1.05–1.36)

5.90 × 10 −3

514/621

1.08(0.91–1.28)

4.05 × 10 −1

1.14(1.03–1.26)

9.87 × 10 −3

 

TT

342/348

1.53(1.27–1.85)

7.87 × 10 −6

171/168

1.32(1.03–1.70)

2.60 × 10 −2

1.45(1.25–1.68)

4.92 × 10 −7

 

Additive

 

1.22(1.12–1.33)

4.93 × 10 −6

 

1.13(1.01–1.27)

3.70 × 10 −2

1.19(1.11–1.27)

6.98 × 10 −7

  1. BP: base position;
  2. a: Adjusted by age, gender, pack-year of smoking and pca1.
  3. b: Adjusted by age, gender and pack-year of smoking.
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