Table 3 Stratification analysis on rs60507107

From: Systematical analyses of variants in CTCF-binding sites identified a novel lung cancer susceptibility locus among Chinese population

 

GWAS

Validation

Variables

Cases/Controls

OR(95% CI)a

P a

P_het b

Cases/Controls

OR(95% CI)c

P c

P_het b

Age

   

1.000

   

0.893

 ≤60

1142/1521

1.22(1.08–1.38)

2.00E-03

 

515/689

1.14(0.97–1.35)

1.19E-01

 

 >60

1189/1556

1.22(1.08–1.38)

1.00E-03

 

600/657

1.12(0.95–1.32)

1.64E-01

 

Gender

   

0.368

   

0.182

 Male

1711/2086

1.20(1.08–1.33)

1.00E-03

 

731/875

1.07(0.92–1.24)

3.66E-01

 

 Female

620/991

1.29(1.09–1.53)

3.00E-03

 

384/471

1.27(1.04–1.56)

1.70E-02

 

Smoking status

   

0.143

   

0.773

 Current

1252/1083

1.21(1.07–1.37)

2.00E-03

 

437/515

1.14(0.94–1.38)

1.75E-01

 

 Former

254/226

0.95(0.73–1.24)

7.30E-01

 

102/114

0.98(0.65–1.48)

9.15E-01

 

 Never

825/1768

1.28(1.12–1.46)

3.59E-04

 

576/717

1.15(0.98–1.35)

8.80E-02

 

Smoking level

   

0.888

   

0.405

 ≤25

1245/2327

1.19(1.07–1.33)

2.00E-03

 

747/974

1.17(1.02–1.35)

2.50E-02

 

 >25

1086/750

1.22(1.06–1.41)

6.00E-03

 

368/372

1.05(0.85–1.30)

6.34E-01

 

Histology

   

0.275

   

0.819

 SC

822

1.14(1.00–1.30)

4.20E-02

 

332

1.15(0.96–1.39)

1.29E-01

 

 AC

1304

1.29(1.17–1.43)

6.63E-07

 

783

1.12(0.98–1.27)

8.60E-02

 

 other

205

1.14(0.91–1.41)

2.47E-01

 

NA

NA

NA

 
  1. a: Adjusted by age, gender, pack-year of smoking and pca1 where is appropriate b: P value for Cochran's chi-square-based heterogeneity test; c: Adjusted by age, gender and pack-year of smoking where is appropriate; NA: not available.
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