Figure 1 | Scientific Reports

Figure 1

From: Activation of Sonic hedgehog signaling in ventricular cardiomyocytes exerts cardioprotection against ischemia reperfusion injuries

Figure 1

Activation of SHH signaling shortens QT interval in healthy animals.

(A) ECGs were acquired over 6 hours after different treatments (i.p.-injected), in control animals. Representative ECGs recorded in control, N-SHH- and MPsSHH+-treated animals indicate a shortening of QT interval after SHH signaling pathway activation. (B) Mean QTc values recorded before (t = 0, left column) and 6 hours after injection (t = 6, right column) of the vehicle (control, n = 5), N-SHH (n = 8), N-SHH+Hexamethonium (N-SHH+Hex, n = 6), MPsSHH+ (n = 7), N-SHH and cyclopamine (N-SHH+Ccl, n = 6) and cyclopamine alone (Control + Ccl, n = 6). (* p < 0.05, QTc at 6 h vs t = 0).

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