Figure 4 | Scientific Reports

Figure 4

From: Activation of Sonic hedgehog signaling in ventricular cardiomyocytes exerts cardioprotection against ischemia reperfusion injuries

Figure 4

SHH activates an inward rectifying potassium current glibenclamide-sensitive.

(A) Family of current difference measured before and after application of glibenclamide from -120 mV to 0 mV in the absence (black traces) or in the presence of SHH (grey traces). (B) Average steady state currents expressed as current density are represented in control (n = 8) and SHH (n = 8). Similar experiments were also performed in the presence ODQ (n = 6) and L-NNA (n = 6). (C) The average current density at -120 mV. (D) The average current density at −60 mV. * and #, p < 0.05 compare to control vs N-SHH.

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