Figure 7 | Scientific Reports

Figure 7

From: Activation of Sonic hedgehog signaling in ventricular cardiomyocytes exerts cardioprotection against ischemia reperfusion injuries

Figure 7

Activation of the SHH pathway decreases the infarct size in a rat model of IR.

(A) Representative sections (Upper) of TTC-stained hearts. (B) Quantification was analyzed by normalizing the infarct area (IA) to the area at risk (AAR). Treatment with N-SHH reduced infarct size after 24 h of reperfusion and this cardioprotective effect was prevented by cyclopamine. (C) No significant difference was observed in the total AAR between groups. Data are expressed as mean ± SEM (control n = 6, N-SHH n = 8, N-SHH + Ccl n = 6; * p < 0.05 vs control).

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