Figure 8 | Scientific Reports

Figure 8

From: Activation of Sonic hedgehog signaling in ventricular cardiomyocytes exerts cardioprotection against ischemia reperfusion injuries

Figure 8

Activation of SHH signaling improves ventricular repolarization after ischemia-reperfusion.

(A) ECGs were acquired over 24 h of reperfusion following 30min ischemia, in animal treated (i.v. injected 15 min prior reperfusion) either with the vehicle, recombinant N-SHH, or N-SHH + Cyclopamine (Ccl). Typical ECGs at 6 hours post reperfusion exhibited an enlargement of QT interval corrected for heart rate (QTc). (B) Time course of QTc variation is summarized in the 3 different experimental conditions. (C) Summarizes the number of arrhythmias recorded over a period of 2 hours following reperfusion showing a reduction of ventricular arrhythmia when SHH signaling pathway is activated. (D) Three representative patterns of ventricular arrhythmias (indicated by arrows) recorded after reperfusion in animals treated with the vehicle only (control). (control n = 6, N-SHH n = 8, N-SHH + Ccl n = 6; * p < 0.05).

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