Figure 2 | Scientific Reports

Figure 2

From: Optimal microdomain crosstalk between endoplasmic reticulum and mitochondria for Ca2+ oscillations

Figure 2

Mitochondria serve as Ca2+ reservoirs.

(a) Oscillations of: [Ca2+]Mic in the IP3R-MCU microdomain, [Ca2+]Cyt in the cytosol, [Ca2+]Mt in mitochondria and [Ca2+]ER in the ER in the presence of mitochondria with a IP3R-MCU distance of 35 nm. The width at half maximum, the rising duration and decay duration of [Ca2+]Cyt spike are marked in the second panel of (a). (b) Oscillations of: [Ca2+]Cyt in the cytosol and [Ca2+]ER in the ER in the absence of mitochondria. [IP3] = 0.5 μM. The unit of [Ca2+] is μM.

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