Figure 5
From: Optimal microdomain crosstalk between endoplasmic reticulum and mitochondria for Ca2+ oscillations
Ca2+ dynamics modulated by [IP3].
(a) The bifurcation diagram (the stable steady states and the maxima and minima of Ca2+ oscillations) of the model with [IP3] as the bifurcation parameter at distance r = 200 (green), 100 (purple), 40 (red), 20 (dark) and 10 nm (grey). (b) The value of [IP3] at the right bifurcation point plotted against distance. The inset is the bifurcation diagram at distance r = 60 nm, in which the arrow marks the right bifurcation point. (c) The maximal [Ca2+]Cyt against the IP3R-MCU distance for [IP3] = 0.1 (lozenges), 0.5 (squares), 1.0 (circles), 2.0 (triangles) and 5.0 μM (stars). The dashed and dotted lines represent [Ca2+]Cyt = 4 and 5 μM, respectively.
