Figure 6
From: Optimal microdomain crosstalk between endoplasmic reticulum and mitochondria for Ca2+ oscillations
Robustness of Ca2+ dynamics on nIP3R.
(a) The fraction of Ca2+ accumulated by mitochondria of the total amount of Ca2+ released from the ER during each oscillating cycle plotted against IP3R-MCU distance. (b) The value of [IP3] at the right bifurcation point against distance. (c) The maximal [Ca2+]Cyt against the IP3R-MCU distance at saturating [IP3] = 5.0 μM. The dashed and dotted lines represent [Ca2+]Cyt = 4 and 5 μM, respectively. Here nIP3R = 3 (stars), 4 (circles) and 5 (triangles).
