Table 2 Meta-analysis of the association between PLCE1 rs2274223 A > G polymorphism and cancer risk
From: Association between PLCE1 rs2274223 A > G polymorphism and cancer risk: proof from a meta-analysis
Variables | G vs. A | GG vs. AA | GA vs. AA | GG/GA vs. AA | GG vs. GA/AA | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P OR a | P het b | OR (95% CI) | P OR a | P het b | OR (95% CI) | P OR a | P het b | OR (95% CI) | P OR a | P het b | OR (95% CI) | P OR a | P het b | |
All | 1.15 (1.06–1.25) | 0.001 | 0.000 | 1.30 (1.10–1.55) | 0.003 | 0.000 | 1.18 (1.08–1.30) | 0.001 | 0.000 | 1.20 (1.08–1.32) | 0.000 | 0.000 | 1.22 (1.04–1.42) | 0.012 | 0.001 |
Cancer Type | |||||||||||||||
GC | 1.11 (0.95–1.31) | 0.184 | 0.000 | 1.26 (0.94–1.68) | 0.118 | 0.010 | 1.12 (0.92–1.37) | 0.253 | 0.000 | 1.14 (0.93–1.39) | 0.217 | 0.000 | 1.22 (0.96–1.54) | 0.100 | 0.057 |
ESCC | 1.25 (1.08–1.44) | 0.002 | 0.000 | 1.55 (1.17–2.06) | 0.002 | 0.015 | 1.27 (1.09–1.47) | 0.002 | 0.034 | 1.30 (1.10–1.53) | 0.002 | 0.004 | 1.39 (1.10–1.77) | 0.007 | 0.059 |
EAC | 1.07 (0.88–1.29) | 0.503 | 0.883 | 1.17 (0.75–1.81) | 0.495 | 0.474 | 1.05 (0.81–1.37) | 0.707 | 0.511 | 1.07 (0.83–1.37) | 0.601 | 0.720 | 1.14 (0.75–1.74) | 0.534 | 0.333 |
Colorectal | 1.02 (0.53–1.95) | 0.948 | 0.001 | 0.74 (0.13–4.33) | 0.742 | 0.003 | 1.17 (0.71–1.92) | 0.532 | 0.038 | 1.10 (0.58–2.10) | 0.760 | 0.005 | 0.71 (0.15–3.44) | 0.668 | 0.006 |
HNC | 1.14 (0.95–1.38) | 0.167 | / | 1.70 (1.02–2.86) | 0.044 | / | 1.03 (0.81–1.30) | 0.807 | / | 1.09 (0.87–1.37) | 0.430 | / | 1.69 (1.01–2.81) | 0.045 | / |
SCCHN | 1.07 (0.94–1.21) | 0.291 | / | 1.09 (0.81–1.45) | 0.580 | / | 1.13 (0.94–1.35) | 0.183 | / | 1.12 (0.95–1.33) | 0.188 | / | 1.02 (0.78–1.35) | 0.878 | / |
GBC | 1.09 (0.85–1.40) | 0.512 | / | 0.52 (0.24–1.12) | 0.094 | / | 1.49 (1.07–2.09) | 0.020 | / | 1.35 (0.98–1.88) | 0.068 | / | 0.42 (0.20–0.89) | 0.024 | / |
Publication Biasc | 0.846 | 0.586 | 0.831 | 0.983 | 0.580 | ||||||||||
