Figure 6
5-aza enhances the immune-modulation and migration ability of hMSCs in DSS-induced colitis mice.
(A) hMSCs with or without 5-aza treatment were injected into mice with DSS-induced colitis. Body weight loss and survival rate were monitored. Number of mice for each group: (-) = 7, (+) = 9, hMSC = 10, 5-aza treated hMSC = 8. (B) The colon length was measured and shown in a graph. Number of mice for each group: (-) = 7, (+) = 9, hMSC = 10, 5-aza treated hMSC = 8. (C) CFDA-SE-labeled hMSCs were detected through confocal image analysis. Bar, 100 μm. (D) The hMSC distribution in colon tissues was analyzed using real-time qPCR of the human-specific ALU gene. *, p < 0.05; **, p < 0.01; ***, p < 0.001. Results are shown as mean ± SD.
