Table 3 Univariate and multivariate analysis of prognostic factors for overall survival (n = 27)

From: Concurrent radiotherapy and weekly chemotherapy of 5-fluorouracil and platinum agents for postoperative locoregional recurrence of oesophageal squamous cell carcinoma

 

Univariate analysis

Multivariate analysis

Variable

P value

P value

HR (95%CI)

Gender (male vs. female)

0.783

  

Age (<60 years vs. ≥60 years)

0.338

  

BMI (<18.5 kg/m2 vs. ≥18.5 kg/m2)

0.783

  

ECOG PS (0 – 1 vs.2)b

0.036

0.014

4.392 (1.352–14.269)

CCI (0 vs. 1 – 2)

0.897

  

Location of primary tumor (upper vs. middle vs. lower)

0.222

  

Operation (Two-incision vs. Three-incision)b

0.192

0.855

 

Postoperative Stage (I – II vs. III)a

0.566

  

Adjuvant chemotherapy (yes vs. no)

0.834

  

Recurrence Time (≥1 year vs. <1 year)

0.684

  

Recurrence site (AR vs. LR)

0.509

  

Radiation techniques (3D-CRT vs. IMRT)

0.209

  

Radiation dose (≥56 Gy vs. <56 Gy)

0.274

  

Chemotherapy (CF vs. NF)

0.440

  

Tumor Response (CR/PR vs. SD/PD)b

0.000

0.000

0.065 (0.014–0.301)

  1. Abbreviations: 3D-CRT = three-dimensional conformal radiotherapy; AR = anastomosis with/without lymphadenopathy; BMI = body mass index; CCI = Charlson comorbidity index; CF = cisplatin + 5-Fu; CI = confidence interval; CR = complete remission; ECOG PS = Eastern Cooperative Oncology Group Performance Status Scale; HR = Hazard ratio; IMRT = intensity-modulated radiotherapy; LR = supraclavicular and/or regional lymph node; NF = nedaplatin + 5-Fu; PD = progressive disease; PR = partial remission; SD = stable disease;
  2. aTNM stage was according to the 7th edition of the American Joint Commission on Cancer (AJCC) staging system.
  3. bTumor response, ECOG PS and operation type were selected for further multivariate analysis as they showed a P value <0.20 in univariate analysis.
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