Figure 1
From: Serotonin Deficiency Exacerbates Acetaminophen-Induced Liver Toxicity In Mice
Dose-response for the effect of APAP on serum ALT and AST, histological examination, liver index and hepatic GSH in Wild-type and TPH1-/- mice.
Mice (n = 6) were given an i.p. injection of acetaminophen (50–400 mg/kg for 24 hours). The liver injury in surviving mice was measured by (A) serum ALT and AST and Liver tissue were obtained at 24 hours after APAP administration at the dose of 150, 300 and 500 mg/kg. (B) H&E staining, (C) liver index, hepatic necrosis area and hepatic GSH content were adopted to evaluate the different hepatotoxicity between Wild-type and TPH1-/- mice. The data are presented as mean ± S.D. *P < .0.05 vs WT group, **P < .0.01 vs WT group.
