Figure 2
From: Serotonin Deficiency Exacerbates Acetaminophen-Induced Liver Toxicity In Mice
Time course for the effect of APAP on serum ALT and AST, histological examination, liver index and hepatic GSH in Wild-type and TPH1-/- mice.
Mice (n = 6) were treated with a 300 mg/kg dose of APAP and sacrificed at the indicated times and serum and liver were collected. The 0 time is the mice in both WT and KO receiving no APAP administration. (A) Serum ALT and AST levels. Liver tissue were obtained at 1, 8 and 24 hours after a dose of 300 mg/kg APAP administration. (B) H&E staining, (C) liver index, hepatic necrosis area and hepatic GSH levels in liver were used to assess the difference between Wild-type and TPH1-/- mice. The data are presented as mean ± S.D. *P < .0.05 vs WT group, **P < .0.01 vs WT group.
