Figure 1 | Scientific Reports

Figure 1

From: FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach

Figure 1

The diagram of a systems pharmacology approach.

A systems pharmacology approach was developed to identify the mechanism-of-action of NSAIDs and investigate potential molecular mechanisms of NSAID-induced liver injury by incorporating network analysis, molecular modeling and in vitro assays. (A) Construction of drug-SE association network by integrating data from five public databases. (B) Construction of liver gene-disease association network. (C) Inferring new candidate off-target proteins involved in NSAID-drug-induced liver injury and validating its molecular mechanism using the in vitro assays. SE: side effects, NSAID: Non-steroidal anti-inflammatory drug.

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