Figure 3 | Scientific Reports

Figure 3

From: FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach

Figure 3

Identifying the NSAID-protein interaction network that is associated with drug-induced liver toxicity using the molecular modeling and network analysis.

(A) Liver disease-gene association network, in which 9 liver disease terms (gold squares) and 627 genes (cyan diamonds) were connected if a gene is a known liver disease-associated genes annotated in four public databases. (B) Prediction of new NSAID-protein (off-target) interaction networks, in which a NSAID (green circle) and a protein encoded by the liver-disease associated gene are connected if the docking scores of NSAID-protein complex is higher than the average docking scores. 10 gene symbols labeled by red represent significantly predicted NSAID off-target proteins (P < 0.01). The detailed data are provided in Supplementary Tables S1 and S2.

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