Figure 5 | Scientific Reports

Figure 5

From: FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach

Figure 5

Indomethacin and ibuprofen regulate FXR downstream target gene mRNA expression in HepG2 cells.

HepG2 cells were incubated with 50 μM CDCA alone or in combination with different concentrations indomethacin (A,B) or ibuprofen (C,D) for 24 h and cDNA synthesized from isolated mRNA served as template in qPCR experiments. The data were carried out in at least three independent experiments. Significance was determined by t test (*P < 0.05 versus cells treated with CDCA).

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