Figure 6 | Scientific Reports

Figure 6

From: FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach

Figure 6

Indomethacin induce liver injury related biochemical events in HepG2 cell.

(A) Indomethacin induces STAT3 phosphorylation in a dose-dependent manner. The HepG2 cells were grown to about 70% to 80% confluence in complete medium and then cultured in low serum medium in the presence of CDCA or indomethacin at the concentration indicated. The phosphorylated STAT3 was determined by western blot analysis. (B) CDCA could suppress indomethacin-induced caspase9 activation. HepG2 cells were treated with indomethacin or CDCA for indicated concentrations and the protein level of caspase9 and GAPDH were detected by western blot.

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