Figure 7
From: Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison
In vivo effects of candesartan and valsartan in post-MI rats overexpressing adrenal βarr1.
(A) Trichrome-Masson's staining in myocardial cross-sections from post-MI rats overexpressing βarr1 specifically in their adrenals and treated for 7 days with either vehicle or 10 mg/kg body weight/day candesartan or 40 mg/kg body weight/day irbesartan (all via drinking water). Blue denotes collagen fibers, red denotes muscle fibers and black represents cell nuclei. Representative images are shown from 5–6 rat hearts stained per group, along with staining in sham-operated rat hearts, in which no blue staining was detectable. (B,C) Heart mRNA levels of (B) collagen I (Col1a1) and brain natriuretic peptide (BNP) (C) in these rats at the end of the 7-day drug treatments. Values for post-MI rats receiving AdGFP in their adrenals instead of Adβarr1 (i.e. not overexpressing βarr1 in their adrenals) were used as reference. *, p < 0.05, vs. Candesartan (Adβarr1), n = 5 rat hearts/group.
