Figure 5
From: Elabela-Apelin Receptor Signaling Pathway is Functional in Mammalian Systems
Relaxing effect of ELA and apelin-13 on blood vessels.
Mouse aortic rings were first treated with vasoconstrictor U46619 (30 nM) to cause contraction and then with accumulated dose of ELA or apelin in intact or endothelium-depleted (denuded) vessels (A and C) for relaxation. Changes in tension were expressed as the percentage decrease in reference to precontraction tension. For L-NAME experiment, aortic rings were pretreated with 1 mM L-NAME for 30 min, then induced to contraction by U46619, followed by ELA. Values are means ± SEM. (n = 5–10). **p < 0.01, compared to aortas with endothelium at the same concentration points of the compound.
