Table 2 Association between individual SNP and KD risk

From: Systematic Confirmation Study of GWAS-Identified Genetic Variants for Kawasaki Disease in A Chinese Population

rs ID

 

HW/HT/HV frequency

HT vs HW

HV vs HW

Dominant model

Recessive model

Additive model

Ref/Var

KD cases

Controls

OR† (95%CI) P‡

OR† (95%CI) P‡

OR† (95%CI) P‡

OR† (95%CI) P‡

OR† (95%CI) P‡

rs1801274

A/G

212/185/27

213/226/52

0.82 (0.63–1.08) 0.157

0.52 (0.31–0.86) 0.011

0.77 (0.59–0.99) 0.045

0.57 (0.35–0.93) 0.024

0.76 (0.62–0.94) 0.010

rs1870740

T/C

201/181/35

226/205/47

1.00 (0.78–1.31) 0.972

0.84 (0.52–1.35) 0.471

0.97 (0.74–1.26) 0.797

0.84 (0.53–1.33) 0.460

0.95 (0.77–1.16) 0.598

rs6554112

A/G

182/202/41

240/200/52

1.33 (1.01–1.75) 0.041

1.04 (0.66–1.64) 0.866

1.27 (0.98–1.65) 0.072

0.90 (0.59–1.39) 0.646

1.12 (0.92–1.37) 0.249

rs4834340

G/A

351/74/1

411/78/1

1.11 (0.78–1.57) 0.554

1.17 (0.07–18.85) 0.913

1.11 (0.79–1.57) 0.549

1.15 (0.07–18.50) 0.923

1.11 (0.79–1.56) 0.549

rs3818298

T/C

149/205/72

141/265/87

0.73 (0.55–0.98) 0.037

0.78 (0.53–1.15) 0.216

0.74 (0.56–0.98) 0.038

0.95 (0.67–1.34) 0.765

0.86 (0.71–1.04) 0.115

rs2857151

G/A

206/180/30

243/197/42

1.08 (0.82–1.42) 0.600

0.84 (0.51–1.39) 0.503

1.04 (0.80–1.35) 0.797

0.81 (0.50–1.33) 0.408

0.98 (0.80–1.21) 0.878

rs2736340

T/C

254/151/17

272/169/40

0.96 (0.72–1.26) 0.749

0.45 (0.25–0.82) 0.009

0.86 (0.66–1.12) 0.265

0.46 (0.26–0.83) 0.010

0.81 (0.65–1.00) 0.052

rs9937546

T/C

385/36/0

439/46/2

0.89 (0.57–1.41) 0.625

NA

0.86 (0.54–1.35) 0.499

NA

0.83 (0.53–1.28) 0.391

rs2233152

G/A

355/62/4

413/77/2

0.94 (0.65–1.35) 0.724

2.33 (0.42–12.81) 0.331

0.97 (0.68–1.39) 0.876

2.35 (0.43–12.92) 0.325

1.01 (0.72–1.41) 0.949

rs4813003

C/T

173/201/47

173/227/79

0.88 (0.67–1.17) 0.395

0.59 (0.39–0.90) 0.015

0.81 (0.62–1.06) 0.123

0.64 (0.43–0.94) 0.022

0.80 (0.66–0.97) 0.023

  1. Abbreviations: Ref, Reference allele; Var, Variant allele; HW, wild type homozygote; HT, heterozygote; HV, variant homozygote; KD, Kawasaki disease; OR, odds ratio; CI, confidence interval; NA, not available.
  2. †OR calculation was conducted under assumption that variant alleles were risk alleles.
  3. ‡All the P values were adjusted for gender. The significant level was corrected with the formula of α’ = α/10*5 = 0.001 according to the Bonferroni method. The nominal significant results were in bold.
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