Figure 4
From: Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor
Structural changes of RXR-DBDs induced by the half-site sequence.
Significant differences in RXR-DBD positioning and in the dimerization interface are observed for the natural DR1s. (a–c) Superimposed crystal structures of RXR-DBD-Ramp2 (cyan) with RXR-DBD-Nr1d1 (a; orange), RXR-DBD-Gde1SpA (b; green) and RXR-DBD-idDR1 (c; blue). Superposition was performed on the 3′ bound RXR-DBD. The largest differences are observed for the idDR1 as indicated by red arrows. Differences are also observed for the complex with the natural Gde1SpA DR1. (d) Superimposed crystal structures of RXR DBD-Ramp2 (cyan) with RAR-RXR DBD-idDR1 (PDB ID: 1XDK, red). Superposition was performed on the 3′ bound RXR-DBD. (e–f) Dimerization interface that involves the DNA minor groove, hydrogen-bonding between atoms of the 2 subunits (residues highlighted) and Van der Waals interactions for RXR-DBD-Ramp2 (e) and RXR-DBD-idDR1 (f).
