Figure 4 | Scientific Reports

Figure 4

From: Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming

Figure 4

Inhibition of TGF-β signaling rescues the H3K27me3 mediated MET defect.

(a) Schematic representation for OSKM transduction, GSK and SB treatment during hFib reprogramming. (b) E-Cadherin DAB staining of OSKM transduced cultures treated with indicated inhibitors. (c) Total number of E-cadherin positive colonies from OSKM, OSKM+GSK and OSKM+GSK+SB cultures. (d) Relative expression of indicated mRNAs from OSKM, OSKM+GSK and OSKM+GSK+SB reprogramming cultures.

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