Table 3 Stratification analysis for associations between variant genotypes of PIK3R1and ESCC risk

From: Associations of PI3KR1 and mTOR Polymorphisms with Esophageal Squamous Cell Carcinoma Risk and Gene-Environment Interactions in Eastern Chinese Populations

 

           PIK3R1 3730089

           PIK3R1 3730090

 

(cases/controls)

     

(cases/controls)

     

Variables

GG

AG/AA

Crude OR (95% CI)

P

Adjusted OR (95% CI)

P a

P hom

CC

CT/TT

Crude OR (95% CI)

P

Adjusted ORa (95% CI)

P a

P hom

Age

              

 ≤60

373/365

192/190

0.99 (0.77–1.23)

0.929

0.97 (0.74–1.25)

0.790

0.853

415/420

150/132

1.13 (0.87–1.49)

0.363

1.20 (0.90–1.59)

0.222

0.455

 >60

363/364

187/196

0.96 (0.75–1.23)

0.726

1.03 (0.79–1.34)

0.844

 

422/429

128/131

0.98 (0.74–1.29)

0.873

0.96 (0.72–1.28)

0.770

 

Sex

              

 Females

153/152

65/82

0.79(0.53–1.17)

0.236

0.78 (0.51–1.18)

0.248

0.174

158/181

60/53

1.27 (0.83–1.95)

0.266

1.40 (0.88–2.22)

0.153

0.337

 Males

582/576

314/305

1.02 (0.84–1.24)

0.825

1.08 (0.88–1.33)

0.450

 

679/668

217/213

1.01 (0.81–1.25)

0.948

0.98(0.78–1.23)

0.871

 

Smoking status

              

 Never

286/321

149/182

0.92 (0.70–1.20)

0.538

0.92 (0.70–1.21)

0.542

0.556

318/386

115/115

1.21 (0.90–1.64)

0.203

1.25 (0.92–1.71)

0.157

0.239

 Ever

450/408

230/204

1.02 (0.81–1.29)

0.852

1.06 (0.83–1.36)

0.620

 

519/463

159/148

0.96 (0.74–1.24)

0.745

0.99 (0.76–1.30)

0.957

 

Drinking status

              

 Never

416/494

202/252

0.95 (0.76–1.19)

0.670

0.97 (0.76–1.22)

0.776

0.257

450/565

166/178

1.17 (0.92–1.50)

0.207

1.16 (0.90–1.50)

0.256

0.271

 Ever

298/235

199/134

0.97 (0.73–1.28)

0.832

1.09 (0.81–1.47)

0.574

 

387/284

108/85

0.93 (0.68–1.29)

0.670

0.90 (0.63–1.25)

0.507

 

BMI

              

 <25.0

485/320

235/164

0.95(0.74–1.21)

0.677

0.95(0.74–1.22)

0.696

0.583

541/365

179/119

1.02 (0.78–1.33)

0.903

1.02 (0.78–1.33)

0.897

0.784

 ≥25.0

251/409

143/222

1.05(0.81–1.37)

0.717

1.03 (0.79–1.35)

0.824

 

297/484

97/147

1.08 (0.80–1.45)

0.632

1.10 (0.82–1.49)

0.530

 
  1. CI, confidence interval; OR, odds ratio.
  2. aObtained in logistic regression models with adjustment for age, sex, smoking status and drinking status.
  3. Phom derived from the homogeneity test.
  4. The results were in bold, if the 95% CI excluded 1 or P < 0.05.
Back to article page