Table 4 Stratification analysis for associations between variant genotypes of mTOR and ESCC risk

From: Associations of PI3KR1 and mTOR Polymorphisms with Esophageal Squamous Cell Carcinoma Risk and Gene-Environment Interactions in Eastern Chinese Populations

 

         mTOR rs1057079

         mTOR rs1014261

 

(cases/controls)

     

(cases/controls)

     

Variables

TT

CT/CC

Crude OR (95% CI)

P

Adjusted OR (95% CI)

P a

P hom

AA

AG/GG

Crude OR (95% CI)

P

Adjusted ORa (95% CI)

P a

P hom

Age

              

 ≤60

364/362

201/193

1.04 (0.81–1.32)

0.780

1.05 (0.81–1.37)

0.692

0.550

464/468

101/87

1.16 (0.84–1.58)

0.368

1.20 (0.86–1.67)

0.276

0.727

 >60

338/363

212/197

1.15 (0.90–1.47)

0.261

1.15 (0.89–1.48)

0.284

 

451/477

99/83

1.25 (0.91–1.72)

0.172

1.27 (0.91–1.77)

0.167

 

Sex

              

 Females

142/150

76/84

0.96 (0.65–1.41)

0.818

1.01 (0.67–1.53)

0.956

0.453

179/201

39/33

1.33 (0.80–2.20)

0.273

1.24 (0.71–2.15)

0.451

0.665

 Males

560/575

336/306

1.13 (0.93–1.37)

0.225

1.13 (0.93–1.39)

0.226

 

737/744

159/137

1.17 (0.91–1.50)

0.215

1.17 (0.99–1.52)

0.243

 

Smoking status

              

 Never

267/314

166/188

1.04 (0.80–1.35)

0.780

1.02 (0.77–1.34)

0.897

0.566

352/414

81/87

1.10 (0.79–1.53)

0.594

1.08 (0.77–1.52)

0.678

0.405

 Ever

435/411

246/202

1.15 (0.91–1.45)

0.231

1.21 (0.95–1.54)

0.132

 

564/531

117/83

1.33 (0.98–1.80)

0.069

1.31 (0.95–1.80)

0.104

 

Drinking status

              

 Never

388/480

228/266

1.06 (0.85–1.32)

0.604

1.08 (0.86–1.36)

0.516

0.631

506/636

110/110

1.25 (0.94–1.68)

0.121

1.24 (0.92–1.66)

0.167

0.585

 Ever

314/245

184/124

1.16 (0.87–1.54)

0.309

1.16 (0.86–1.57)

0.322

 

410/309

88/60

1.11 (0.77–1.58)

0.585

1.10 (0.75–1.61)

0.632

 

BMI

              

 <25.0

437/323

283/161

1.30 (1.02–1.65)

0.033

1.31 (1.03–1.67)

0.031

0.022

585/415

135/69

1.39 (1.01–1.91)

0.042

1.39 (1.01–1.92)

0.043

0.167

 ≥25.0

265/402

129/229

0.86 (0.66–1.12)

0.246

0.87 (0.67–1.14)

0.311

 

331/530

63/101

1.00 (0.71–1.41)

0.994

0.99 (0.70–1.40)

0.962

 
  1. CI, confidence interval; OR, odds ratio.
  2. aObtained in logistic regression models with adjustment for age, sex, smoking status and drinking status.
  3. Phom derived from the homogeneity test.
  4. The results were in bold, if the 95% CI excluded 1 or P < 0.05.
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