Table 7 Haplotype analysis for genotypes of mTOR and ESCC risk

From: Associations of PI3KR1 and mTOR Polymorphisms with Esophageal Squamous Cell Carcinoma Risk and Gene-Environment Interactions in Eastern Chinese Populations

 

    Haplotype frequencies

    
 

Cases (N = 2232)

Controls (N = 2234)

    

Haplotypes a

n

%

n

%

Crude OR (95% CI)

P

Adjusted OR (95% CI)

P a

T-T-A

1700

76.23

1746

78.72

1.00

0.009

1.00

 

T-C-A

23

1.03

9

0.41

2.63 (1.21–5.69)

0.015

2.96 (1.32–6.67

0.023

T-C-G

19

0.85

6

0.27

3.25 (1.30–8.16)

0.012

2.97 (1.16–7.60)

0.024

G-T-A

40

1.79

18

0.81

2.28 (1.30–4.00)

0.004

2.41 (1.34–4.37)

0.003

G-T-G

33

1.48

27

1.22

1.26 (0.75–2.10)

0.385

1.38 (0.81–2.35)

0.234

T-C-G

265

11.88

271

12.22

1.01 (0.84–1.21)

0.963

1.03 (0.85–1.24)

0.795

G-T-A

150

6.73

141

6.36

1.09 (0.86–1.39)

0.468

1.12 (0.87–1.43)

0.380

  1. aObtained in logistic regression models with adjustment for age, sex, smoking status and drinking status.
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