Figure 3
Impaired BA homeostasis in Cic-L-/- mice.
(a) Pictures showing the size of gallbladders in WT and Cic-L-/- mice at P18. GB, L and I mean gallbladder, liver and intestine, respectively. Arrows indicate the gallbladder. (b) Hepatic and small intestinal BA levels and total BA pool size in WT and Cic-L-/- mice (n = 4~7 per each genotype) at P18. ***P<0.001. All error bars show s.e.m. (c) qRT-PCR analysis for levels of Shp and key genes involved in BA biosynthesis and transport in livers from 18 day-old WT and Cic-L-/- mice (n = 4~9 per each genotype). #P = 0.054, **P<0.01 and ***P<0.001. All error bars show s.e.m. (d) qRT-PCR analysis for levels of membrane transporter genes in livers from 18 day-old WT and Cic-L-/- mice (n = 3~6 per each genotype). *P<0.05, **P<0.01 and ***P<0.001. All error bars show s.e.m.
