Table 2 Results of haplotype analysis of the LD block identified by single point association analysis

From: Association of genetic variants of GRIN2B with autism

HAPLOTYPE

FREQ.tios

FREQ.cc

F_A.cc

F_U.cc

T.trios

U.trios

CHISQ.cc

CHISQ.trios

P.cc

P.trios

P.comb

G

0.824

0.813

0.8494

0.8077

91

49

3.106

12.60

0.07802

3.86E-04

1.73E-04

GC

0.820

0.810

0.8567

0.8074

92

49

4.304

13.11

0.03802

2.93E-04

5.64E-05

GCG

0.806

0.810

0.8576

0.8074

107.1

58.93

4.496

13.98

0.03397

1.84E-04

3.42E-05

GCGC

0.800

0.800

0.8537

0.8038

109.1

59.93

4.365

14.31

0.03667

1.55E-04

3.29E-05

GCGCG

0.776

0.787

0.856

0.7978

119.1

63.93

5.773

16.64

0.01628

4.52E-05

4.58E-06

GCGCGG

0.772

0.782

0.8556

0.7995

122.1

61.93

5.377

19.68

0.02040

9.16E-06

1.78E-06

GCGCGGG

0.758

0.761

0.8288

0.7893

126.1

65.95

2.533

18.83

0.11150

1.43E-05

2.74E-05

GCGCGGGG

0.758

0.761

0.8372

0.7904

126.1

65.95

3.546

18.83

0.05968

1.43E-05

1.08E-05

GCGCGGGGG

0.637

0.627

0.6764

0.6541

167.1

98.39

0.573

17.77

0.44920

2.49E-05

4.38E-04

GCGCGGGGGA

0.636

0.625

0.6719

0.6537

167.1

97.38

0.384

18.36

0.53530

1.82E-05

5.23E-04

GCGCGGGGGAG

0.636

0.625

0.672

0.6565

167.1

97.39

0.278

18.36

0.59810

1.83E-05

6.67E-04

  1. Note: Haplotype GCGCGGGGGAG involved SNPs are rs7970177|rs1805474|rs888150|rs1805510|rs2268097|rs2300238|rs980365|rs2268102|rs2284406|rs1008619|rs918065. Haplotype association analysis was performed using PLINK with a sliding window. P.cc represents P values of the case-control cohort; P.trios represents P values of the trios cohort; P.comb represents P values after meta-analysis.
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