Figure 4
From: The molecular architecture of dihydropyrindine receptor/L-type Ca2+ channel complex
Model of physical coupling between DHPR and RyR1.
Due to the mobile nature of the II–III loop of the DHPR α1 subunit, it might be difficult for it to find its coupling site in RyR1 without the interaction of the β subunit of DHPR with RyR1 (left panel); with the docking of the β subunit to RyR1, which might act as an “anchor” and a “fulcrum” of the DHPR complex due to its rigid nature, the II–III loop of DHPR α1 subunit could find and interact with its coupling site in RyR1 and transmit the signal from DHPR to RyR1during excitation-contraction coupling (right panel).
