Figure 1

Structure of Adenylate Kinase.

AK has three domains, called CORE, LID and NMP and two distinct binding sites. The LID and NMP domains are colored green (residues 118–160) and yellow (residues 30–67), respectively. The CORE domain is colored in gray (residues 1–29, 68–117, 161–214) and the P-loop is colored in orange (residues 7–13). Specifically, ATP, that is complexed with Mg⁺², is bound between the CORE and LID domains, in the so called ATP binding site, while AMP is sandwiched between CORE and NMP, in the AMP binding site. ATP and AMP ligands are represented as ball and stick.