Table 1 Gene- and most significant SNP-based P-values for inositol phosphate metabolism pathway genes and risk of cancer
From: Genetic variants in the inositol phosphate metabolism pathway and risk of different types of cancer
Types of cancer (Pathway P*) | Gene | Chr. (cytoband) | Gene-level Pg | No. of SNPs | Most significant SNP | Associated SNP Pn |
|---|---|---|---|---|---|---|
Lung cancer | ||||||
(2.00E-04) | CALM3 | 19q13 | 2.20E-03 | 5 | rs11083841 | 3.68E-04 |
ITPKC | 19q13 | 3.95E-03 | 8 | rs11668501 | 5.90E-04 | |
INPP5D | 2q37 | 7.70E-03 | 50 | rs13021302 | 2.07E-04 | |
PI4KA | 22q11 | 9.35E-03 | 10 | rs2072513 | 1.24E-03 | |
IMPA1 | 8q21 | 1.26E-02 | 1 | rs1967328 | 1.18E-02 | |
PIP5K1C | 19p13 | 1.42E-02 | 8 | rs2270083 | 2.10E-03 | |
PLCG1 | 20q12-q13 | 1.55E-02 | 4 | rs2235360 | 4.96E-03 | |
PIK3CB | 3q22 | 2.27E-02 | 8 | rs531577 | 5.89E-03 | |
PIK3CD | 1p36.2 | 3.06E-02 | 8 | rs12075554 | 4.34E-03 | |
PIK3C3 | 18q12 | 3.23E-02 | 8 | rs3764459 | 6.79E-03 | |
PLCE1 | 10q23 | 3.56E-02 | 57 | rs11187842 | 1.04E-03 | |
INPP5J | 22q12 | 3.85E-02 | 19 | rs4820944 | 2.54E-03 | |
PIP4K2C | 12q13 | 3.95E-02 | 4 | rs775250 | 1.22E-02 | |
INPP5K | 17p13 | 4.10E-02 | 10 | rs1879488 | 6.00E-03 | |
PIKFYVE | 2q34 | 4.25E-02 | 13 | rs10189031 | 8.82E-03 | |
PI4KB | 1q21 | 4.30E-02 | 7 | rs5022636 | 1.34E-02 | |
PI4K2B | 4p15 | 4.31E-02 | 7 | rs3115231 | 9.19E-03 | |
ESCC | ||||||
(5.70E-03) | PLCE1 | 10q23 | 5.00E-05 | 60 | rs3765524 | 5.55E-08 |
ITPKA | 15q15 | 2.60E-03 | 2 | rs2305030 | 1.50E-03 | |
SYNJ2 | 6q25 | 6.60E-03 | 36 | rs2025641 | 3.00E-04 | |
INPP5A | 10q26 | 8.60E-03 | 28 | rs10747068 | 5.00E-04 | |
INPP4B | 4q31 | 1.89E-02 | 109 | rs336407 | 3.00E-04 | |
GC | ||||||
(3.03E-02) | PLCE1 | 10q23 | 5.00E-05 | 60 | rs3781264 | 4.18E-11 |
ITPKC | 19q13 | 1.28E-02 | 7 | rs890934 | 2.40E-03 | |
ITPKB | 1q42 | 1.56E-02 | 25 | rs3754378 | 1.00E-03 | |
INPPL1 | 11q13 | 3.93E-02 | 5 | rs7110260 | 9.00E-03 | |
MINPP1 | 10q23 | 4.32E-02 | 13 | rs3843597 | 5.30E-03 | |
INPP5A | 10q26 | 4.65E-02 | 28 | rs7091957 | 3.20E-03 | |
RCC | ||||||
(1.26E-02) | PLCB1 | 20p12 | 8.50E-04 | 248 | rs4813865 | 4.30E-05 |
IP6K1 | 3p21 | 9.50E-04 | 5 | rs6802890 | 1.97E-04 | |
IP6K2 | 3p21 | 4.70E-03 | 6 | rs3172494 | 9.78E-04 | |
PLCG1 | 20q12-q13 | 2.20E-02 | 7 | rs6129760 | 4.59E-03 | |
IP6K3 | 6p21 | 2.31E-02 | 26 | rs471942 | 1.03E-03 | |
SYNJ2 | 6q25 | 4.74E-02 | 40 | rs12663163 | 1.76E-03 | |
Pancreatic cancer | ||||||
(1.40E-01) | PLCD1 | 3p22-p21 | 1.25E-03 | 8 | rs11922130 | 1.79E-04 |
PLCH2 | 1p36 | 2.84E-02 | 10 | rs7535528 | 3.26E-03 | |
CALM3 | 19q13 | 2.91E-02 | 6 | rs7258489 | 5.56E-03 | |
IMPA2 | 18p11 | 4.13E-02 | 25 | rs1262056 | 2.13E-03 | |
NUDT3 | 6p21.2 | 4.30E-02 | 6 | rs206937 | 1.19E-02 | |
PIK3C2G | 12p12 | 4.34E-02 | 86 | rs11044171 | 9.79E-04 | |
ITPKB | 1q42.13 | 4.62E-02 | 26 | rs10916019 | 2.62E-03 | |
Prostate cancer | ||||||
(4.51E-01) | PLCD1 | 3p22-p21 | 1.23E-02 | 7 | rs4389435 | 2.14E-03 |
ITPKC | 19q13 | 1.94E-02 | 7 | rs3865451 | 3.90E-03 | |
IMPAD1 | 8q12.1 | 4.06E-02 | 7 | rs13257046 | 6.65E-03 | |
Breast cancer | ||||||
(3.04E-01) | PIK3C2B | 1q32 | 1.53E-02 | 17 | rs2271421 | 6.59E-03 |
PLCH2 | 1p36 | 2.52E-02 | 11 | rs2236395 | 2.57E-03 | |
SYNJ2 | 6q25 | 2.80E-02 | 44 | rs2295893 | 8.78E-04 | |
PLCD1 | 3p22-p21 | 2.97E-02 | 17 | rs137625 | 3.51E-03 | |
IMPA2 | 18p11 | 4.12E-02 | 26 | rs684680 | 2.24E-03 | |
INPP5K | 17p13 | 4.41E-02 | 11 | rs7214615 | 6.49E-03 | |
Bladder cancer | ||||||
(6.63E-01) | INPP5K | 17p13 | 2.25E-02 | 1 | rs2270227 | 2.35E-02 |
INPP5D | 2q37 | 4.09E-02 | 24 | rs10933435 | 2.67E-03 |
