Figure 1 | Scientific Reports

Figure 1

From: Lentivirus-mediated Inhibition of Tumour Necrosis Factor-α improves motor function associated with PRDX6 in spinal cord contusion rats

Figure 1

The change of BBB scores and the expression of TNF-α and PRDX6 after cSCI.

(A) The BBB scores of rats with spinal cord contusion. Compared to the sham group, the BBB scores are significantly lower at each time point in the contusion group. The BBB scores increase at 7 dpo and remained so until at least 28d in the SCI group. (B) Bioinformatics show TNF-α and Atf3 are co-expressed, whereas PRDX6 co-expressed with Atf4. At the same time, Atf3 and Atf4 have the same structural domain, thus TNF-α might be associated with PRDX6. (C) The expression of TNF-α mRNA is significantly increased at 6 h, 24 h and 14 d after cSCI in the rats. (D) The level of PRDX6 mRNA is detected using qRT-PCR, which significantly decreased at 6 h, 12 h, 24 h, 3 d, 5 d, 7 d, 14 d and 28 d after cSCI. Values are expressed in mean ± SED * p < 0.05 vs. sham group.

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