Figure 6 | Scientific Reports

Figure 6

From: Neuroinflammation and Aβ Accumulation Linked To Systemic Inflammation Are Decreased By Genetic PKR Down-Regulation

Figure 6

Schematic representation of PKR-dependent Aβ production in brain after systemic inflammation.

Peripheral inflammation communicates with the brain through the blood-brain barrier to induce microglial activation and pro-inflammatory cytokines production, involving PKR pathway. Cytokines, including TNFα, activate PKR in neurons leading to Aβ production. Thereof could be controlled by the activation of transcription factor STAT3.

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