Figure 3
The genetic architecture of LGALS1 gene.
The upper panel denotes the chromosomal region that accommodates the LGALS1 gene. The region flanking the transcriptional start site is a conserved regulatory region containing high LD SNPs in Chinese and other populations. The variants in high LD with anchor SNPs, rs4820294 and rs13057866 (denoted with ★), are shown in the next panel. The underlined variants are those in high LD with rs4820294 while un-marked ones are in high LD with rs13057866. Lung eQTL panel shows the locations of eQTL and P values in -log10 scale. The horizontal bar represents the -log10P value of 4. DNAse I hypersensitivity cluster and transcriptional factor binding site signals are annotated according to the experimental data from ENCODE Consortium. The gray box indicates the extent of the hypersensitive region or cluster of transcriptional factor occupancy. The darkness is proportional to the maximum signal strength observed in any cell line. The green line indicates the highest scoring site of an identified canonical motif for the corresponding factor.
