Figure 5
From: Structural basis for PPARγ transactivation by endocrine-disrupting organotin compounds
Mass spectrometry of the PPARγ-LBD complex with TPT (A–C) or TBT (D, E) under non-denaturing conditions.
Mass spectra show that PPARγ forms a complex with TPT (C) or TBT (E) in a 1:1 molar ratio. Mass patterns after the addition of aliquots of formic acid (A, D = 3%, B = 1%) to the complex indicate that the dissociation of the interaction is caused by the unfolding of PPARγ-LBD.
