Table 3 Changes in CD4+ count and blood lipid levels (48-weeks post-treatment)
Total cholesterol (mg/dL) | Triglycerides (mg/dL) | Low-density lipoprotein (mg/dL) | CD4+ count(cells/mm3) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Study | Baseline | Week 48 | Abnormal rate (%)# | Baseline | Week 48 | Abnormal rate (%)$ | Baseline | Week 48 | Abnormal rate (%)∧ | Baseline | ΔCD4+ |
ART-naïve patients | |||||||||||
Walmsley S et al.7 | NA | 53† | 9 | NA | 125† | 9.3 | NA | NA | 260 | 207 | |
Ortiz R et al.8 | NA | NA | 23 | NA | NA | 11 | NA | NA | 10 | 218 | 141 |
Johnson MA et al.10 | 159 | 27† | NA | 137 | 82† | 5 | 96 | 14† | NA | 214 (116–380) ‡ | 185 |
Johnson MA et al.10 | 168 | 27† | NA | 136 | 76† | 4 | 102 | 13† | NA | 232 (95–339)‡ | 188 |
Molina JM et al.12 | 147 | 185 | 18 | 110 | 168 | 4 | 91 | 108 | NA | 204 | 219 |
Eron J Jr et al.13 | 157 | 210 | 9 | 117 | 195 | 8 | 97 | 120 | NA | 194 (79–287)‡ | 191 (124–287)‡ |
Sierra-Madero J et al.14 | NA | 63† | NA | NA | 116† | NA | NA | 10† | NA | 52 (37.1–66.8)‡ | 239 |
ART-experienced patients | |||||||||||
Cohen C et al.15 | 167 | 190 | NA | 162 | 211 | NA | 97 | 103 | NA | 256 | 169 |
Zajdenverg R et al.16 | NA | NA | 6.5 | NA | NA | 4.8 | NA | NA | NA | 239.3 | 153 |
Zajdenverg R et al.16 | NA | NA | 7.5 | NA | NA | 6.4 | NA | NA | NA | 268.3 | 122 |
