Figure 1
A structural diagram of the PP2Cα active site and sequence alignment of the M2 coordinated residues for the PPM family members.
(a) A schematic representation of the active center of human PP2Cα. (b) A multiple amino acid sequence alignment of PP2C family members from Homo sapiens. The 38th residue of PP2Cα and the corresponding amino acid residues of other members are marked in red. Residues involved in the M2 metal ion coordination are shadowed.
